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Invitrogen™ PLK5 Polyclonal Antibody
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Product Code. 15514921
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Quantity:
100 μg
Unit Size:
100µg
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15514921 100 μg 100µg
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Product Code. 15514921 Supplier Invitrogen™ Supplier No. PA537987

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Description

Goat Polyclonal Antibody

This antibody is tested in Peptide ELISA: antibody detection limit dilution 64,000.

Polo-like kinase 5 (PLK5) is a member of the Polo-like kinase family, notable for its involvement in cell cycle regulation processes such as mitotic entry, spindle formation, and cytoplasmic division. PLK5 is distinguished from other family members by its low expression levels, particularly within different immunophenotypes, except for being notably elevated in the C5 subtype. Its expression has been linked to poor prognosis in non-small cell lung cancer, although this is not universally supported by all data sources, suggesting complex roles in tumor biology. In a mouse model, PLK5 functions as a DNA damage-inducible gene with nucleolar localization, facilitated by a specific nucleolus localization signal in its N-terminal. The protein's ectopic expression can lead to G1 phase arrest, indicating its role in cellular response to DNA damage. Research is ongoing to fully elucidate its function and prognostic implications across various cancer types.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PLK5
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Plk5
Gene Accession No. Q496M5
Gene Alias 6330514A18Rik; FG060302; Inactive serine/threonine-protein kinase PLK5; PLK5; PLK-5; PLK5P; polo like kinase 5; polo-like kinase 5; polo-like kinase 5 pseudogene; polo-like kinase 5, pseudogene; serine/threonine-protein kinase PLK5; SgK384ps
Gene Symbols Plk5
Host Species Goat
Immunogen Peptide with sequence SLDVPRSHGCAPTT, from the internal region of PLK5 (aa309-322).
Purification Method Ammonium sulfate precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 126520
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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