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Invitrogen™ Phospho-PKC alpha/beta-2 (Thr638, Thr641) Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5121268
This item is not returnable.
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Description
Positive test controls include: NIH/3T3. The target is usually found in the following locations: Cytoplasm, Membrane, Nucleus, Peripheral membrane protein. Immunogen sequence: VLTPP.
Protein Kinase c alpha (PKC alpha) is an 77 kDa member of the conventional group (cPKCs: sensitive to calcium, diacylglycerol, phosphatidylserine and phorbol esters) of the PKC family of serine/ threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC alpha is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of a broad range of cellular functions including proliferation, differentiation, development, migration, cell cell adhesion, cell extracellular matrix adhesion, and solute transport. The activation loop threonine (threonine 497 in PKC alpha) of conventional PKCs is phosphorylated by phosphoinositide dependent kinase 1 (PDK1). This phosphorylation is necessary for the autophosphorylation of threonine 638 in the carboxy terminus of PKC alpha, a step that is critical for regulating the rate of PKC alpha dephosphorylation and inactivation.
Specifications
| Phospho-PKC alpha/beta-2 (Thr638, Thr641) | |
| Polyclonal | |
| Unconjugated | |
| Prkca | |
| A130082F03Rik; AAG6; aging-associated gene 6; AI875142; PKCA; PKC-A; PKC-alpha; Pkcb; PKC-B; PKC-beta; PRKACA; PRKC Pan; PRKCA; PRKCB; PRKCB1; Prkcb2; protein kinase C alpha; protein kinase C alpha type; protein kinase C beta; protein kinase C beta I; protein kinase C beta II; protein kinase C beta type; protein kinase C beta-II; protein kinase C, alpha; protein kinase C, beta; protein kinase C, beta 1; protein kinase C, beta 1 polypeptide; protein kinase c-alpha | |
| Rabbit | |
| Affinity Chromatography | |
| RUO | |
| 18750, 18751, 24680, 25023, 5578, 5579 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| 0.44 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| P05696, P05771, P17252, P20444, P68403, P68404 | |
| Prkca, PRKCB | |
| A synthetic phosphorylated peptide around T638 of human PKC alpha/beta IIPRKCA (NP_0027282). | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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