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Invitrogen™ Phospho-LATS1/LATS2 (Ser909, Ser872) Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA564591
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Description
Phospho-LATS1/LATS2 (Ser909, Ser872) Polyclonal Antibody detects endogenous levels of LATS1/LATS2 only when phosphorylated at Ser909, Ser872.
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
Specifications
| Phospho-LATS1/LATS2 (Ser909, Ser872) | |
| Polyclonal | |
| Unconjugated | |
| Lats2 | |
| 4932411G09Rik; AV277261; AW208599; AW228608; h-warts; kinase phosphorylated during mitosis protein; KPM; large tumor suppressor; large tumor suppressor 2; large tumor suppressor homolog 1; Large tumor suppressor homolog 2; large tumor suppressor kinase 1; large tumor suppressor kinase 2; large tumor suppressor, homolog 2; large tumor supressor, homolog 1; LATS (large tumor suppressor, Drosophila) homolog 1; LATS (large tumor suppressor, Drosophila) homolog 2; LATS, large tumor suppressor, homolog 1; LATS, large tumor suppressor, homolog 2; lats1; Lats2; RGD1564085; serine/threonine kinase KPM; serine/threonine-protein kinase kpm; Serine/threonine-protein kinase LATS1; serine/threonine-protein kinase LATS2; WARTS; WARTS protein kinase; warts-like kinase; wts | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 16798, 26524, 305922, 308265, 50523, 9113 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot | |
| 1 mg/mL | |
| PBS with 50% glycerol, 0.5% BSA and 0.02% sodium azide; pH 7.4 | |
| O95835, Q7TSJ6, Q8BYR2, Q9NRM7 | |
| Lats1, Lats2 | |
| A synthesized peptide derived from human LATS1/2 (Phospho-Ser909/872). | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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