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Invitrogen™ Phospho-JAK2 (Tyr221) Polyclonal Antibody
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Product Code. 16621155
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Quantity:
100 μL
Unit Size:
100µL
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16621155 100 μL 100µL
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Product Code. 16621155 Supplier Invitrogen™ Supplier No. PA5104703

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of JAK2 only when phosphorylated at Tyrosine 221.

Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains the catalytic domain (JH1) of JAK2. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex. Mutations affecting JAK2 can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-JAK2 (Tyr221)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene JAK2
Gene Accession No. O60674, Q62120, Q62689
Gene Alias EC 2.7.10.2; Fd17; JAK 2; JAK2; JAK-2; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); JTK 10; JTK10; kinase Jak2; THCYT3; Tyrosine-protein kinase JAK2
Gene Symbols JAK2
Host Species Rabbit
Immunogen A synthesized peptide derived from human JAK2(Accession O60674), corresponding to amino acid residues around phosphorylated Tyr221.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16452, 24514, 3717
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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