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  6. Invitrogen™ Phospho-Jak1 (Tyr1022, Tyr1023) Recombinant Rabbit Monoclonal Antibody (Jak1Y10221023-F11), Invitrogen™

Invitrogen™ Phospho-Jak1 (Tyr1022, Tyr1023) Recombinant Rabbit Monoclonal Antibody (Jak1Y10221023-F11), Invitrogen™

Product Code. 17117008 Shop All Thermo Scientific Products
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20 μL
200 μL
Unit Size:
200µL
20µL
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17117008 20 μL 20µL
17146758 200 μL 200µL
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Product Code. 17117008 Supplier Invitrogen™ Supplier No. MA537415

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Description

Rabbit Recombinant Monoclonal Antibody

Janus kinase 1 (JAK1), is a protein tyrosine kinase that is involved in the interferon-alpha/beta and -gamma signal transduction pathways. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-Jak1 (Tyr1034, Tyr1035)
Applications Flow Cytometry
Classification Recombinant Monoclonal
Clone Jak1Y10221023-F11
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.10% BSA, 50% glycerol and 0.02% sodium azide
Gene JAK1
Gene Accession No. P23458, P52332
Gene Alias AA960307; BAP004; C130039L05Rik; EC 2.7.10.2; Jak1; JAK-1; JAK1A; JAK1B; Janus kinase 1; Janus protein tyrosine kinase 1; JTK3; kinase Jak1; Tyrosine-protein kinase JAK1
Gene Symbols JAK1
Host Species Rabbit
Immunogen A synthetic phospho-peptide corresponding to residues surrounding Tyr1034/1035 of human phospho-Jak1.
Purification Method Protein A/G
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16451, 3716
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG κ
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