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Invitrogen™ Phospho-IkB beta (Thr19, Ser23) Polyclonal Antibody
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Product Code. 11302972
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Quantity:
100 μL
Unit Size:
100µL
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11302972 100 μL 100µL
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Product Code. 11302972 Supplier Invitrogen™ Supplier No. PA517517

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Description

Rabbit Polyclonal Antibody

It is not recommended to aliquot this antibody.

The NF-kB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IkB proteins. Most agents that activate NF-kB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of IkB. The key regulatory step in this pathway involves activation of a high molecular weight IkB kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits. IKK alpha and IKK beta serve as the catalytic subunits of the kinase and IKK gamma serves as the regulatory subunit. Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKK beta (Ser176 and Ser180 in IKK alpha), which causes conformational changes, resulting in kinase activation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-IkB beta (Thr19, Ser23)
Applications Western Blot
Classification Polyclonal
Concentration 8 μg/mL
Conjugate Unconjugated
Formulation 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
Gene NFKBIB
Gene Accession No. Q15653
Gene Alias I kappa B beta; I(Kappa)B(beta); ikappaBbeta; I-kappa-B-beta; IkB; IKB B; IKB beta; Ikbb; ikB-B; IkBbeta; ikB-beta; NF kappa BIB; NF-kappa-B inhibitor beta; NF-kappa-BIB; NFKB inhibitor beta; NFKBIB; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta; Thyroid receptor; thyroid receptor-interacting protein 9; TR-interacting protein 9; TRIP 9; TRIP9; TRIP-9
Gene Symbols NFKBIB
Host Species Rabbit
Immunogen Synthetic phosphopeptide corresponding to residues of human IkB beta surrounding pThr19/Ser23.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4793
Target Species Human, Non-human Primate
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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