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Invitrogen™ Phospho-Elk1 (Ser389) Polyclonal Antibody

Product Code. 16601285
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. Quantity unitSize
16601285 100 μL 100µL
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Product Code. 16601285 Supplier Invitrogen™ Supplier No. PA5104833

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of ELK1 only when phosphorylated at Serine 389.

ELK1 is a component of the ternary complex that binds the serum response element (SRE) and mediates gene activity in response to serum and growth factors. ELK1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C-terminus. Phosphorylation at these sites, particularly Ser383, is critical for transcriptional activation by ELK1. ELK1 appears to be a direct target of activated MAP kinase. Biochemical studies indicate that ELK1 is a good substrate for MAP kinase, the kinetics of ELK1 phosphorylation and activation correlate with MAP kinase activity, and interfering mutants of MAP kinase block ELK1 activation in vivo. ELK1 is a nuclear target for the ras-raf-MAPK signaling cascade. Alternatively spliced transcript variants encoding the same protein have been found for ELK1.
TRUSTED_SUSTAINABILITY

Spécification

Antigen Phospho-Elk1 (Ser389)
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene ELK1
Gene Accession No. A4GTP4, P19419, P41969
Gene Alias ELK 1; ELK1; Elk-1; ELK1, ETS transcription factor; ELK1, member of ETS oncogene family; ETS domain-containing protein Elk-1; ETS transcription factor ELK1; ETS-like gene 1; Oncogene Elk1; tyrosine kinase (ELK1) oncogene
Gene Symbols ELK1
Host Species Rabbit
Immunogen A synthesized peptide derived from human ELK1(Accession P19419), corresponding to amino acid residues around phosphorylated Ser389.
Purification Method sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13712, 2002, 314436
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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