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Phospho-Caspase 1 (Ser376) Polyclonal Antibody, Invitrogen™

Product Code. 15595481
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Quantity:
100 μg
Unit Size:
100µg
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15595481 100 μg 100µg
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Product Code. 15595481 Supplier Invitrogen Supplier No. PA538565

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Description

Rabbit Polyclonal Antibody

Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis (1). The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a tetramer to form the active enzyme. Caspase-1/ICE (IL-1b converting enzyme) is similar to the cell death gene CED-3 of Caenorhabditilis elegans and regulates multiple proinflammatory cytokines, including interleukin-1b and interferon-gamma-inducing factor.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-Caspase 1 (Ser376)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
Gene CASP1
Gene Accession No. P29466, P29452
Gene Alias ICE, IL1BC, P45, CASP1 nirs variant 1, IL-1 beta-converting enzyme, IL1B-convertase, caspase 1, apoptosis-related cysteine peptidase interleukin 1, beta, convertase, caspase-1, interleukin 1, beta, convertase, interleukin 1-B converting enzyme
Gene Symbols CASP1
Host Species Rabbit
Immunogen A synthetic phosphopeptide derived from human Caspase 1 around the phosphorylation site of Ser376 (R-F-SP-F-E)
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12362, 834
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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