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  6. Invitrogen™ Phospho-beta Arrestin 1 (Ser412) Recombinant Rabbit Monoclonal Antibody (23GB3845), Invitrogen™

Invitrogen™ Phospho-beta Arrestin 1 (Ser412) Recombinant Rabbit Monoclonal Antibody (23GB3845), Invitrogen™

Product Code. 30088391
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Quantity:
20 μL
100 μL
Unit Size:
100µL
20µL
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Product Code. Quantity unitSize
30088391 20 μL 20µL
30087664 100 μL 100µL
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Product Code. 30088391 Supplier Invitrogen™ Supplier No. MA553649

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Description

Rabbit Recombinant Monoclonal Antibody

Beta Arrestin 1 is a member of a family of proteins widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling and mediates agonist-dependent desensitization and internalization of Gprotein-coupled receptors (GPCRs, e.g., beta 2-adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G-protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-beta Arrestin 1 (Ser412)
Applications Flow Cytometry, Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone 23GB3845
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene ARRB1
Gene Accession No. P49407
Gene Alias 1200006I17Rik; ARB1; ARR1; ARRB1; ARRB1 protein; arrdc1; arrestin; arrestin 2; arrestin beta 1; arrestin beta-1; arrestin, beta 1; arrestin-2; AW208571; BARRES; beta-arrestin; beta-arrestin1; beta-arrestin-1; G430100A01Rik; Non-visual arrestin-2
Gene Symbols ARRB1
Host Species Rabbit
Immunogen A synthetic peptide of human Phospho-beta Arrestin 1 (Ser412) (405-418AA).
Purification Method Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 408
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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