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PFN1 Mouse anti-Human, CoraLite 594, Clone: 3A12E8, Proteintech

Product Code. 17264826 Shop All Proteintech Products
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. Quantity Unit Size
17264826 100 μL 100µL
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Product Code. 17264826 Supplier Proteintech Supplier No. CL59467390100UL
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Description

Mouse Monoclonal Antibody

Profilin-1 (PFN1) plays an important role in the control of actin dynamics, and could represent an important therapeutic target in several diseases. PFN1 is identified as a huntingtin aggregation inhibitor, and may serves as a tumor-suppressor. PFN1 is crucial for the conversion of monomeric (G)-actin to filamentous (F)-actin. Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disorder resulting from motor neuron death. Cells expressing PFN1 mutants contain ubiquitinated, insoluble aggregates that in many cases contain the ALS-associated protein TDP-43. Recently, PFN1 is a potential biomarker for bladder cancer aggressiveness and may be of great clinical importance.

Specifications

Antigen PFN1
Applications Immunofluorescence
Classification Monoclonal
Clone 3A12E8
Concentration 991 μg/mL
Conjugate CoraLite 594
Host Species Mouse
Quantity 100 μL
Primary or Secondary Primary
Gene ID (Entrez) 5216
Target Species Human, Mouse, Rat
Form Liquid
Isotype IgG2b
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