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PF 477736, Tocris Bioscience™
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Product Code. 18035622
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18035622 50 mg 50mg
18035302 10 mg 10mg
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Product Code. 18035622 Supplier Tocris Bioscience Supplier No. 4277/50

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Description

Selective Chk1 inhibitor

Selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively). Abrogates cell cycle arrest at S and G2-M checkpoints; sensitizes cells to DNA damage. Enhances docetaxel (Cat. No. 4056) efficacy in tumor cells and xenografts.
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Chemical Identifiers

CAS 952021-60-2
Molecular Formula C22H25N7O2
Molecular Weight (g/mol) 419.489
InChI Key YFNWWNRZJGMDBR-LJQANCHMSA-N
Synonym unii-xo23pgz0sm, xo23pgz0sm, 2r-2-amino-2-cyclohexyl-n-2-1-methyl-1h-pyrazol-4-yl-6-oxo-5,6-dihydro-1h-1,2 diazepino 4,5,6-cd indol-8-yl-acetamide, r-2-amino-2-cyclohexyl-n-2-1-methyl-1h-pyrazol-4-yl-6-oxo-5,6-dihydro-1h-1,2 diazepino 4,5,6-cd indol-8-yl acetamide, 2r-2-amino-2-cyclohexyl-n-2-1-methylpyrazol-4-yl-9-oxo-3,10,11-triazatricyclo 6.4.1.0?, 1 3 trideca-1,4,6,8 13 ,11-pentaen-6-yl acetamide, d0u9iq, cyclohexaneacetamide, alpha-amino-n-5,6-dihydro-2-1-methyl-1h-pyrazol-4-yl-6-oxo-1h-pyrrolo 4,3,2-ef 2,3 benzodiazepin-8-yl-, alphar, pf hplc, ar-, a-amino-n-5,6-dihydro-2-1-methyl-1h-pyrazol-4-yl-6-oxo-1h-pyrrolo 4,3,2-ef 2,3 benzodiazepin-8-yl cyclohexaneacetamide, 2∼ r-2-azanyl-2-cyclohexyl-∼ n-2-1-methylpyrazol-4-yl-9-oxidanylidene-3,10,11-triazatricyclo 6.4.1.0^ 4,13 trideca-1,4,6,8 13 ,11-pentaen-6-yl ethanamide
PubChem CID 16750408
SMILES CN1C=C(C=N1)C2=NC3=C4C2=CNNC(=O)C4=CC(=C3)NC(=O)C(C5CCCCC5)N

Specifications

Quantity 50 mg
Formula Weight 419.48
Percent Purity >99%
Chemical Name or Material PF 477736
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