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Tocris Bioscience™ PF 06726304 acetate
GREENER_CHOICE

Highly potent and SAM-competitive EZH2 inhibitor

Brand:  Tocris Bioscience™ 6169/10

Encompass

Product Code. 15746825

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Description

Description

PF 06726304 acetate is a highly potent and SAM-competitive EZH2 lysine methyltransferase inhibitor (IC50 = 0.7 nM). Inhibits proliferation of Karpas-422 cells (non-Hodgkin's lymphoma) in vitro, and halts tumor growth and reduces intratumoral H3K27Me3 levels in mice.
Specifications

Specifications

PF 06726304 acetate
10 mg
Solid
Bioactive Small Molecule
5,8-Dichloro-2-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-7-(3,5-dimethyl-4-isoxazolyl)-3,4-dihydro-1(2H)-isoquinolinone acetate
Soluble to 100mM in DMSO and to 100mM in ethanol
White
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