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Tocris Bioscience™ PF 06726304 acetate
Highly potent and SAM-competitive EZH2 inhibitor
Brand: Tocris Bioscience™ 6169/10
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Description
PF 06726304 acetate is a highly potent and SAM-competitive EZH2 lysine methyltransferase inhibitor (IC50 = 0.7 nM). Inhibits proliferation of Karpas-422 cells (non-Hodgkin's lymphoma) in vitro, and halts tumor growth and reduces intratumoral H3K27Me3 levels in mice.Specifications
| PF 06726304 acetate | |
| 10 mg | |
| Solid | |
| Bioactive Small Molecule |
| 5,8-Dichloro-2-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-7-(3,5-dimethyl-4-isoxazolyl)-3,4-dihydro-1(2H)-isoquinolinone acetate | |
| Soluble to 100mM in DMSO and to 100mM in ethanol | |
| White |
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