PERK Monoclonal Antibody (5G5), Invitrogen™

Description

MA5-15705 targets EIF2AK3 in indirect ELISA, WB applications and shows reactivity with Human samples. The MA5-15705 immunogen is purified recombinant fragment of human EIF2AK3 expressed in E. Coli. MA5-15705 detects EIF2AK3 which has a predicted molecular weight of approximately 125kDa.

EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.