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Gibco™ PeproGMP™ Human Activin A Recombinant Protein, PeproTech®

Product Code. 30275960
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Quantity:
100 μg
50 μg
Unit Size:
100µg
50µg
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Product Code. 30275960

Brand: Gibco™ GMP12014E100UG

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This item is not returnable. View return policy

Description

Recombinant Protein

PeproTech Recombinant Human Activin A is a 26.0 kDa disulfide-linked homodimer of two beta-A chains, each containing 116 amino acid residues. Reconstitute using sterile water (i.e., WFI) to a concentration of 0.1-1.0 mg/ml. Additional product information, specifications, handling and reconstitution information are provided on the Certificate of Analysis. All PeproGMP™ products are manufactured using animal-derived component free materials. Product Description/Intended Use: PeproTech GMP recombinant proteins are manufactured for use as ancillary materials by applying applicable principles of GMP and quality control requirements from USP (United States Pharmacopeia) Chapter <1043> Ancillary Materials for Cell, Gene, and Tissue-Engineered Products.

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Activin A mutations are associated with fibrodysplasia ossificans progressive.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P08476
For Use With (Application) Control, Western Blot Control, Bioactivity
Format Lyophilized
Formulation Protein with no preservative
Gene ID (Entrez) 3624
Molecular Weight (g/mol) 26 kDa
Name PeproGMP™ Human Activin A
Purification Method Purified
Quantity 100 μg
Storage Requirements -20°C or -80°C if preferred
Regulatory Status GMP
Endotoxin Concentration ≤0.1 EU/μg
Gene Alias activin A; activin beta-A chain; BMP7; BMP-7; Bone morphogenetic protein 7; EDF; Eptotermin alfa; erythroid differentiation factor; erythroid differentiation protein; follicle-stimulating hormone-releasing protein; FRP; FSH-releasing protein; INHB; Inhba; inhibin B subunit; inhibin beta A chain; inhibin beta A protein; inhibin beta A subunit; inhibin beta-A; inhibin beta-A-subunit; inhibin beta-subunit; inhibin subunit beta A; inhibin, beta A; inhibin, beta A (activin A, activin AB alpha polypeptide); Inhibin, beta-1; OP1; OP-1; Osteogenic protein 1; unnamed protein product
Common Name Activin A
Gene Symbol Inhba
Biological Activity Determined by the proliferation of mouse MPC-11 cells. PeproGMP Recombinant Human Activin A has been tested against the WHO standard NIBSC 91/626.
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Sequence GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS
Content And Storage -20°Cor to +80°C if preferred
Activity Determined by the proliferation of mouse MPC-11 cells. PeproGMP Recombinant Human Activin A has been tested against the WHO standard NIBSC 91/626. Find the International Unit (IU) value <a href='https://www.thermofisher.com/us/en/home/life-science/cell-culture/cell-culture-learning-center/recombinant-protein-information/international-units.html'>here</a>.
Expression System E. coli
Form Lyophilized
Product Line PeproGMP
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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