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Invitrogen™ PDCD5 Polyclonal Antibody
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Product Code. 17247533 Shop All Thermo Scientific Products
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100 μL
Unit Size:
100µL
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17247533 100 μL 100µL
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Product Code. 17247533 Supplier Invitrogen™ Supplier No. PA5114769

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total PDCD5.

Programmed cell death 5 (PDCD5), a human apoptosis-related protein, is thought to play an early and universal role in apoptosis. PDCD5 is widely expressed and is upregulated in cells undergoing apoptosis, where it translocates rapidly from the cytoplasm to the nucleus. PDCD5 has a compact core structure of low flexibility with two mobile alpha-helices at N-terminal and a flexible unstructured C-terminal region. The charged residues are crucial for the ability of apoptosis-promoting and cell translocation of the protein. PDCD5 can facilitate apoptosis and enhance TAJ/TROY-induced paraptosis-like cell death. PDCD5 may play a dual role in the Tip60 pathway. It interacts with Tip60 and functions as a Tip60 co-activator to promote apoptosis. The nucleotide polymorphisms in the 5'-upstream region of PDCD5 affect promoter activity and the susceptibility of a Chinese population to develop chronic myelogenous leukemia and may represent a novel tumor suppressor gene influencing lung cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PDCD5
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene PDCD5
Gene Accession No. O14737, P56812
Gene Alias 2200003D22Rik; AA408513; PDCD5; programmed cell death 5; programmed cell death protein 5; Protein TFAR19; TF1 cell apoptosis-related gene 19; TF-1 cell apoptosis-related protein 19; Tfar19; TFAR19 novel apoptosis-related
Gene Symbols PDCD5
Host Species Rabbit
Immunogen A synthesized peptide derived from human PDCD5(Accession O14737), corresponding to amino acid residues E94-Y125.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 56330, 9141
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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