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PD-L1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA528115
Additional Details : Weight : 0.01000kg
Description
Recommended positive controls: A431, MDA-MB-231, MDA-MB-231 (24 μg/mL Tunicamycin treatment for 16 hr), MDA-MB-231, A549 (100 ng/mL IFN-gamma treatment for 48 hr), A431 (100 ng/mL IFN-gamma treatment for 48 hr). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion.Specifications
PD-L1 | |
Polyclonal | |
Unconjugated | |
Cd274 | |
A530045L16Rik; B7 homolog 1; B7-H; B7h1; B7-H1; Cd274; CD274 antigen; CD274 molecule; PDCD1 ligand 1; Pdcd1l1; Pdcd1lg1; Pdl1; PD-L1; pdl-1; Programmed cell death 1 ligand 1; programmed death ligand 1; RGD1566211; sCD274; soluble CD274; soluble PD L1; sPD L1 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
29126 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot | |
0.29 mg/mL | |
PBS with 20% glycerol and 0.025% ProClin 300; pH 7 | |
Q9NZQ7 | |
Cd274 | |
Synthetic peptide corresponding to a region within amino acids 230 and 290 of CD274 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |