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DiscoverX PathHunter™ eXpress DDR1 Functional Assay

Product Code. 17313979
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Quantity:
1,000 dp (10 x 96-well)
Unit Size:
1 set
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17313979 1,000 dp (10 x 96-well) 1 set
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Product Code. 17313979 Supplier DiscoverX Supplier No. 930894E3CP16L

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Description

The PathHunter™ eXpress DDR1 Functional Assay measures DDR1 receptor tyrosine kinase activity via ligand-induced SH2 domain protein recruitment. eXpress kits contain all assay materials: cells, reagents, and plates.

The PathHunter™ eXpress DDR1 Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated DDR1 dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cells overexpress PK-tagged DDR1 and an EA-tagged SH2 domain protein. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.

Specifications

Assay Entry Receptor Phosphorylation
For Use With (Application) Assay-Ready eXpress Kits
Primary Agonist Bovine Type II Collagen, Immunization Grade
Quantity 1,000 dp (10 x 96-well)
Target Entry DDR1
Cell Line U2OS
Target DDR1
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