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Invitrogen™ p35 Polyclonal Antibody
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Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA578263

Product Code. 16356964

  • 568.00 € / 100µL

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Description

Description

Positive Control: HeLa Predicted Reactivity: Mouse (100%), Rat (100%), Bovine (100%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

p35
Polyclonal
Unconjugated
Cdk5r1
23 kDa subunit of tau-protein kinase II; cdk5 activator; CDK5 activator 1; CDK5P35; Cdk5r; Cdk5r1; cyclin dependent kinase 5 regulatory subunit 1; cyclin-dependent kinase 5 activator 1; Cyclin-dependent kinase 5 activator 1, p25; Cyclin-dependent kinase 5 activator 1, p35; Cyclin-dependent kinase 5 regulatory subunit 1; cyclin-dependent kinase 5, regulatory subunit (p35) 1; cyclin-dependent kinase 5, regulatory subunit 1 (p35); D11Bwg0379e; NCK5A; neuronal CDK5 activator; p23; p25; P25/P35; p35; p35nck5a; regulatory partner for CDK5 kinase; tau protein kinase II 23 kDa subunit; tau protein kinase II 23kDa subunit; TPKII regulatory subunit
Rabbit
Antigen affinity chromatography
RUO
116671, 12569, 8851
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
0.97 mg/mL
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
P61809, P61810, Q15078
Cdk5r1
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of Human p35. The exact sequence is proprietary.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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Produktforslag

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