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OSU-T315, MedChemExpress

Product Code. 16443597
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Quantity:
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10 mg
50 mg
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50mg
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Product Code. 16443597

Brand: Medchem Express HY18676

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Description

MedChemExpress OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC50 of 0.6 μM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain). OSU-T315 abrogates AKT activation by impeding AKT localization in lipid rafts and triggers caspase-dependent apoptosis in an ILK-independent manner. OSU-T315 causes cell death through apoptosis and autophagy.

OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC50 of 0.6 μM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain). OSU-T315 abrogates AKT activation by impeding AKT localization in lipid rafts and triggers caspase-dependent apoptosis in an ILK-independent manner. OSU-T315 causes cell death through apoptosis and autophagy.

Specifications

Chemical Name or Material OSU-T315
Physical Form Solid
CAS 2070015-22-2
Color White
Quantity 50 mg
Purity Grade Notes Research
Molecular Formula C30H30F3N5O
For Use With (Application) Cancer-Kinase/protease
Solubility Information DMSO : ≥ 260 mg/mL (487.27 mM)
SMILES O=C(NC)CCC1=CC(C2=CC=C(C3=CC=C(C(F)(F)F)C=C3)C=C2)=NN1C4=CC=C(N5CCNCC5)C=C4
Molecular Weight (g/mol) 533.59
Formula Weight 533.59
Percent Purity 98.0%
Grade Research
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Research purposes only

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