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Olodanrigan, MedChemExpress

Product Code. p-200096276
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Product Code. 16498247

Brand: Medchem Express HY131065mg

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Description

MedChemExpress Olodanrigan (EMA401) is a highly selective, orally active, peripherally restricted angiotensin II type 2 receptor (AT2R) antagonist. It is under development as a neuropathic pain therapeutic agent. Olodanrigan (EMA401) analgesic action appears to involve inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons.

Olodanrigan (EMA401) is a highly selective, orally active, peripherally restricted angiotensin II type 2 receptor (AT2R) antagonist. It is under development as a neuropathic pain therapeutic agent. Olodanrigan (EMA401) analgesic action appears to involve inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons.

Specifications

Chemical Name or Material Olodanrigan
CAS 1316755-16-4
Color White
Purity Grade Notes Research
Molecular Formula C32H29NO5
Quantity 5 mg
Synonym EMA401 PD-126055
Solubility Information DMSO : ≥ 34 mg/mL (66.98 mM) ∣H2O : 0.1 mg/mL (0.20 mM; Need ultrasonic)
SMILES O=C([C@H]1N(C(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)CC4=C(C(OCC5=CC=CC=C5)=C(OC)C=C4)C1)O
Molecular Weight (g/mol) 507.58
Formula Weight 507.58
Percent Purity 99.16%
Grade Research
Physical Form Solid
For Use With (Application) Neuroscience-Neuromodulation
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Research purposes only

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