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  5. Tocris Bioscience™ NRX 252114

Tocris Bioscience™ NRX 252114

Product Code. 30023138
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5 mg
25 mg
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25mg
5mg
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30023138 25 mg 25mg
30023129 5 mg 5mg
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Product Code. 30023138 Supplier Tocris Bioscience™ Supplier No. 7990/25

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709.80 EUR valid until 2026-03-31
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Description

Molecular glue Degrader of mutant β-catenin

NRX-252114 is a potent enhancer of the interaction between S37A mutant β-catenin, and its cognate E3 ligase, SCFβ-TrCP (EC50 = 6.5 nM; Kd = 0.4 nM). NRX-252114 is a molecular glue degrader that binds at the phosphoserine binding site on β-TrCP and induces mutant β-catenin ubiquitination and subsequent degradation.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 2-[[4-[(2,6-Dichlorophenyl)thio]-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-pyridinyl]carbonyl]-2,3-dihydro-1H-isoindole-4-carbonitrile
CAS 2763260-39-3
Quantity 25 mg
Target Molecular Glues
Molecular Formula C22H12Cl2F3N3O2S
Purity 0.98
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