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Tocris Bioscience™ NR 162

Product Code. 18737786
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10 mg
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Product Code. 18737786 Supplier Tocris Bioscience™ Supplier No. 7572/10

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250.80 EUR valid until 2026-03-31
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Description

Potent and selective calcium/calmodulin-dependent serine protein kinase (CASK) inhibitor

NR 162 is a potent and selective calcium/calmodulin-dependent serine protein kinase (CASK) inhibitor (IC50 = 80 nM); it exhibits no significant activity against related kinases MERTK, AXL and ABL1 and ~ 47-fold selectivity over TYRO3 (IC50 = 3.8 μM). NR 162 targets the unique pocket created by CASK GFG motif; it is a type-I inhibitor which stabilizes the active state of CASK without affecting the scaffolding function. NR 162 induces cell death in actively differentiating cells of the P19 neuronal differentiation model. NR 162 shows no toxicity in differentiated cells, or in cancer cells.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 4-(Cyclopentylamino)-2-((2,5-dibromo-4-methylbenzyl)amino)-N-(3-(2-oxooxazolidin-3-yl)propyl)pyrimidine-5-carboxamide
CAS 2755241-73-5
Quantity 10 mg
Target CaM Kinase Inhibitors
Molecular Formula C24H30Br2N6O3
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