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Invitrogen™ NPTX2 Polyclonal Antibody
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Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA588307

Product Code. 16526591

  • 518.00 € / 100µL

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Description

Description

Immunogen sequence: KLARCEGLAG GKARGAGATG KDTMGDLPRD PGHVVEQLSR SLQTLKDRLE SLEHQLRANV SNAGLPGDFR EVLQQRLGEL ERQLLRKVAE LEDEKSLLHN ETSAHRQKTE STLNALLQRV TELERGNSAF KSPDAFKVSL PLRTNYLYGK I; Positive Samples: SH-SY5Y, BxPC-3, LO2.

Neuronal pentraxin (NPTX) 2 was initially identified as a member of the pentraxin family having high homology to NPTX1. Unlike NPTX1 however, NPTX2 is expressed in testes, pancreas, liver, heart, skeletal muscle as well as brain. NPTX2 possesses the lectin properties common to the pentraxin family, promotes neurite outgrowth, and is rapidly regulated by neuronal activity. NPTX1 and NPTX2 form heterocomplexes that contribute to both activity-independent and -dependent excitatory synaptogenesis. Recently, NPTX2 has been found to be highly upregulated in Parkinsonian substantia nigra and localizes to Lewy bodies and Lewy neurites in sporadic Parkinson's disease (PD), suggesting that it is involved in the pathway dysregulation that underlies PD.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

NPTX2
Polyclonal
Unconjugated
NPTX2
apexin; Narp; neuro activity regulated petaxin; neuronal activity-regulated pentaxin; neuronal activity-regulated pentraxin; neuronal pentraxin 2; neuronal pentraxin II; Neuronal pentraxin-2; NP2; NP-II; Nptx2
Rabbit
Affinity Chromatography
RUO
4885
-20°C, Avoid Freeze/Thaw Cycles
Liquid
ELISA, Western Blot
0.43 mg/mL
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
P47972
NPTX2
Recombinant fusion protein containing a sequence corresponding to amino acids 90-240 of human NPTX2 (NP_0025141).
100 μL
Primary
Human
Antibody
IgG
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