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  8. NPS-2143 hydrochloride, MedChemExpress

NPS-2143 hydrochloride, MedChemExpress

Product Code. 16499956
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Product Code. 16499956 Supplier Medchem Express Supplier No. HY10171

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Description

MedChemExpress NPS-2143 hydrochloride (SB-262470A hydrochloride), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 hydrochloride (SB-262470A hydrochloride) blocks increases in cytoplasmic Ca2+ concentrations (IC50=43 nM) elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+ receptor.

NPS-2143 hydrochloride (SB-262470A hydrochloride), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 hydrochloride (SB-262470A hydrochloride) blocks increases in cytoplasmic Ca2+ concentrations (IC50=43 nM) elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+ receptor.

Specifications

Chemical Name or Material NPS-2143 hydrochloride
CAS 324523-20-8
Color White
Purity Grade Notes Research
Molecular Formula C24H26Cl2N2O2
Quantity 50 mg
Synonym SB-262470A hydrochloride
Solubility Information DMSO : ≥ 100 mg/mL (224.53 mM) ∣H2O : 1.85 mg/mL (4.15 mM; ultrasonic and warming and heat to 60°C)
SMILES N#CC1=C(OC[C@@H](CNC(C)(C)CC2=CC=C3C=CC=CC3=C2)O)C=CC=C1Cl.[H]Cl
Molecular Weight (g/mol) 445.38
Formula Weight 445.38
Percent Purity 99.94%
Grade Research
Physical Form Solid
For Use With (Application) Metabolism-protein/nucleotide metabolism
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Research purposes only

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