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Invitrogen™ NPC1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA599027
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Description
NPC1 Polyclonal Antibody for Western Blot, IHC (P), ELISA
Mutations in the Niemann-Pick disease type C1 (NPC1) gene result in a fatal progressive neurodegenerative disorder characterized by an abnormal sequestration of lipids including cholesterol and glycosphingolipids. The NPC1 protein is a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. NPC1 transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolyzed and released as free cholesterol. NPC1, in addition to FTO, MC4R, and PTER has recently been shown to be a new risk loci for early-onset and morbid adult obesity in European populations.
Specifications
| NPC1 | |
| Polyclonal | |
| Unconjugated | |
| NPC1 | |
| A430089E03Rik; C85354; Cdig2; D18Ertd139e; D18Ertd723e; FLJ98532; I79_014078; lcsd; Niemann Pick type C1; Niemann-Pick C disease protein; niemann-Pick C1 protein; Niemann-Pick disease, type C1; Niemann-Pick type C1; Niemann-Pick type C1 protein; nmf164; NPC; NPC intracellular cholesterol transporter 1; NPC1; sphingomyelinosis; spm; truncated Niemann-Pick C1 | |
| Rabbit | |
| Protein G | |
| RUO | |
| 4864 | |
| -20°C or -80°C if preferred | |
| Liquid |
| ELISA, Immunohistochemistry (Paraffin), Western Blot | |
| 2.55 mg/mL | |
| PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4 | |
| O15118 | |
| NPC1 | |
| Recombinant Human NPC intracellular cholesterol transporter 1 protein (23-269AA). | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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