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  5. Tocris Bioscience™ NMS 873

Tocris Bioscience™ NMS 873
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Product Code. p-7116107
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Product Code. Quantity unitSize
18749126 25 mg 50mg
18758006 5 mg 10mg
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Product Code. 18749126 Supplier Tocris Bioscience™ Supplier No. 6180/25

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414.00 EUR valid until 2026-03-31
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Description

Potent and selective p97 ATPase (VCP) allosteric inhibitor

NMS 873 is a potent p97 ATPase (VCP) allosteric inhibitor (IC50 = 30 nM). Selective over all other AAA ATPases, HSP90 and kinases tested (IC50 >10 μM). Activates the unfolded protein response (UPR) and modulates autophagosome maturation. Exhibits antiproliferative activity in cancer cells in vitro (IC50 values are 400 and 700 nM for HCT116 and HeLa cells respectively). Reduces p97-sensitization to trypsin digestion.
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Specifications

Chemical Name or Material 3-[3-(Cyclopentylthio)-5-[[[2-methyl-4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]pyridine
CAS 1418013-75-8
Assay Percent Range >98%
Quantity 25 mg
Molecular Formula C27H28N4O3S2
Formula Weight Observed MW: 520.67
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