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NLRX1 Mouse anti-Human, Clone: OTI4H8, liquid, TrueMAB™

Product Code. 17522314
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Quantity:
100 μL
Unit Size:
100µL
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17522314 100 μL 100µL
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Product Code. 17522314 Supplier Origene Technologies Supplier No. TA809764

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Description

Mouse Monoclonal Antibody

NLR family member X1 (NLRX1) belongs to the NLRP family and contains four LRR (leucine-rich) repeats and one NATCH domain. NLRX1 localizes to the mitochondrial outer membrane and interacts through the mitochondrial antiviral signalling adaptor MAVS during viral infection. Expression of NLRX1 results in the potent inhibition of RLH- and MAVS-mediated interferon-beta promoter activity and in the disruption of virus-induced RLH-MAVS interactions. It is also reported that NLRX1 synergistically potentiated ROS production induced by tumour necrosis factor alpha, Shigella infection and double-stranded RNA, resulting in amplified NF-kappaB-dependent and JUN amino-terminal kinases-dependent signalling, thus contributing to the link between ROS generation at the mitochondria and innate immune responses.

Specifications

Antigen NLRX1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI4H8
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene NLRX1
Gene Accession No. Q86UT6
Gene Alias CLR11.3, DLNB26, NOD26, NOD5, NOD9
Gene Symbols NLRX1
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 866-975 of human NLRX1 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79671
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2b
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