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N-Acetyl-D-mannosamine, 98%, Thermo Scientific Chemicals

Product Code. 10527970 Shop All Thermo Scientific Chemicals Products
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5 g
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Glass bottle
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Product Code. 10527970 Supplier Thermo Scientific Acros Supplier No. 427530050
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Beskrivning

N-Acetyl-D-mannosamine (ManNAc), CAS # 7772-94-3, is a monosaccharide sialic acid precursor.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • N-Acetyl-D-mannosamine (ManNAc) is a precursor used to synthesize N-acetylneuraminic acid, the most common physiologic sialic acid present in humans and other mammals
  • Sialic acids are terminal sugars on glycoconjugates that can modify biochemistry of glycoproteins and lipids, mediate cellular adhesion, and act as immune regulators
  • Defects in sialic acid biosynthesis are associated with a number of pathologies
  • Sialic acids are often found at increased expression levels on tumor cell surfaces

Applications

  • As a sialic acid precursor, N-Acetyl-D-mannosamine can be used in many glycoengineering applications, such as modifying immune cell activity, imaging glycans, or blocking pathogen binding
  • N-Acetyl-D-mannosamine hasbeen used in preclinical laboratory studies as a treatment for hereditary inclusion body myopathy, a progressive neuromuscular disease via increased sialylation of podocalyxin
  • N-Acetyl-D-mannosamine has been used in laboratory studies to induce IgG sialylation and prevent obesity-induced hypertension in mice following high-fat diet
TRUSTED_SUSTAINABILITY

Kemiska identifierare

CAS 7772-94-3
Molecular Formula C8H17NO7
Molecular Weight (g/mol) 239.22
MDL Number MFCD00149493,MFCD00046758,MFCD00149493,MFCD00069808
InChI Key VVQPUTSNIMAJPT-UHFFFAOYNA-N
Synonym n-acetylmannosamine
PubChem CID 11908605
IUPAC Name N-[(2R,3S,4S,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide
SMILES O.CC(=O)NC1C(O)OC(CO)C(O)C1O

Specifikationer

CAS Min % 97.5
CAS Max % 100.0
Color White
Infrared Spectrum Authentic
Assay Percent Range 98%
Packaging Glass bottle
Quantity 5 g
Formula Weight 221.21
Percent Purity ≥97.5%
Physical Form Crystalline Powder
Chemical Name or Material N-Acetyl-D-mannosamine
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