Invitrogen™ Mouse C/EBP alpha (aa 1-21) Synthetic Peptide

The C/EBP (CCAAT/enhancer binding protein) family of transcription factors--alpha, beta, delta, and epsilon)--are widely expressed proteins found in a variety of tissues. These domains contain an evolutionarily conserved five-amino acid motif (the regulatory domain motif RDM) that conforms to the consensus sequence (I/V/L) KXEP. One of the major roles of these transcription factors is that of metabolic regulation in liver and fat cells. Studies suggest that these transcription factors act in a cascade aiding in the development of the adipose cell. Three C/EBP beta isoforms (LAP*, LAP, and LIP) arise from different translation initiation and display different function in gene regulation. From a neurological standpoint, C/EBPs have been implicated in the mediation of nerve growth factor, altering synaptic plasticity, and mediation of inflammatory response in AD patients. PEP-243 is a 21 amino acid synthetic peptide corresponding to amino acid residues 1-21 from mouse C/EBP. The sequence of this peptide is (amino to carboxy terminus): M H R L L A W D A A C L P P P A A F P K L H.This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product, catalog &Num; MA1-826. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (∽70-fold) for competitive inhibition of antibody-protein binding reactions.Reconstitute with 0.1 mL of distilled water.