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Gibco™ Mouse Adiponectin Recombinant Protein, PeproTech®

Product Code. 17822583
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Product Code. Quantity unitSize
17822583 25 μg 25µg
17832873 100 μg 100µg
17882273 1 mg 1mg
17892273 250 μg 250µg
17852063 500 μg 500µg
17802663 50 μg 50µg
17852863 5 μg 5µg
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Product Code. 17822583 Supplier Gibco™ Supplier No. 3152625UG

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Description

Recombinant Protein

Recombinant Murine Adiponectin is a multimeric glycoprotein containing amino acids Val-21 to Asn-247 of the adiponectin precursor protein fused to an N-terminal histidine tag. As a result of glycosylation, Recombinant Murine Adiponectin migrates with an apparent molecular mass of approximately 31-36 kDa by SDS-PAGE gel, under reducing conditions. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Adiponectin is a protein hormone secreted exclusively by adipocytes that regulates the metabolism of lipids and glucose. Adiponectin has been shown to play a role in various physiological processes including homeostasis and obesity. Decreased levels of adiponectin are associated with obese individuals as well as insulin resistance and hyperinsulinemia (type 2 diabetes). In mice adiponectin has been shown to improve insulin signaling, thus ameliorating insulin resistance. Through activation of AMP kinase and PPAR-alpha, adiponectin can increase fatty acid transport, oxidation, and dissipation in skeletal muscle, leading to a reduction of intramyocellular lipid levels and thus improved insulin signaling.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q60994
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 11450
Molecular Weight (g/mol) 25.8 kDa
Name Mouse Adiponectin
Quantity 25 μg
Source Insect cells
Regulatory Status RUO
Endotoxin Concentration <1 EU/ μg
Gene Alias 30 kDa adipocyte complement-related protein; 30 kDa; Acdc; Acrp30; Ad; adipo; adipocyte complement related protein; adipocyte complement related protein of 30 kDa; adipocyte complement-related 30 kDa protein; adipocyte complement-related protein of 30 kDa; adipocyte, C1Q and collagen domain containing; adipocyte, C1q and collagen domain-containing protein; Adipocyte-specific protein AdipoQ; adiponectin; adiponectin, C1Q and collagen domain containing; Adipoq; Adipose most abundant gene transcript 1 protein; adipose specific collagen-like factor; ADIPQTL1; ADPIOQ; ADPN; Apm1; APM-1; APN; GBP28; Gelatin-binding protein; gelatin-binding protein 28
Common Name Adiponectin
Gene Symbol ADIPOQ
Biological Activity Determined by a cytotoxic assay using M1 cells. The ED50 for this effect is 4.0-6.0 ug/ml
Conjugate Unconjugated
Recombinant Recombinant
Protein Tag His-tag
Sequence RGHHHHHHHH VTTTEELAPA LVPPPKGTCA GWMAGIPGHP GHNGTPGRDG RDGTPGEKGE KGDAGLLGPK GETGDVGMTG AEGPRGFPGT PGRKGEPGEA AYVYRSAFSV GLETRVTVPN VPIRFTKIFY NQQNHYDGST GKFYCNIPGL YYFSYHITVY MKDVKVSLFK KDKAVLFTYD QYQEKNVDQA SGSVLLHLEV GDQVWLQVYG DGDHNGLYAD NVNDSTFTGF LLYHDTN
Content And Storage -20°C
Expression System Insect cells
Form Lyophilized
Purity or Quality Grade ≥ 95% by SDS-PAGE gel and HPLC analyses.
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