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MG-132, MedChemExpress

Product Code. 16486136
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Product Code. 16486136 Supplier Medchem Express Supplier No. HY13259

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Description

MedChemExpress MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC50s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activator. MG-132 also induces apoptosis.

MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC50s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activator. MG-132 also induces apoptosis.

Specifications

Chemical Name or Material MG-132
Physical Form Solid
CAS 133407-82-6
Color White
Quantity 100 mg
Purity Grade Notes Research
Molecular Formula C26H41N3O5
For Use With (Application) Cancer-Kinase/protease
Synonym Z-Leu-Leu-Leu-al MG132
Solubility Information DMSO : 16.67 mg/mL (35.05 mM; ultrasonic and warming and heat to 60°C)
SMILES O=C(OCC1=CC=CC=C1)N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C([H])=O)CC(C)C)=O)=O)CC(C)C
Molecular Weight (g/mol) 475.62
Formula Weight 475.62
Percent Purity 98.0%
Grade Research
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