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Methotrexate disodium salt, 98.5%, Thermo Scientific™
Methotrexate disodium salt, CAS # 7413-34-5, is the sodium salt of methotrexate that shows antineoplastic, antirheumatic, dermatologic, and immunosuppressive activities.
Brand: Thermo Scientific Alfa Aesar J66364.MD
| Quantity | 250mg |
|---|
This item is not returnable.
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Description
This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.
General Description
• Methotrexate disodium salt is an organic sodium salt derived from methotrexate with antineoplastic, antirheumatic, dermatologic, and immunosuppressive activities
• It acts as an enzyme inhibitor of dihydrofolate reductase
• It binds to and inhibits purine nucleotide and thymidylate synthesis, leading to the inhibition of DNA and RNA synthesis. Because of this mechanism of action, the methotrexate disodium salt is defined as a nucleic acid synthesis inhibitor
Application
• Methotrexate disodium salt is a folic acid antagonist with the ability to inhibit folic acid metabolism
• In vitro studies demonstrated that methotrexate disodium salt has potent activity against pyrimethamine-resistant Plasmodium vivax malaria parasites
• This compound has been used in chimeric polymersomes in order to investigate its effect in lung tumor xenografts in mice
Specifications
| 7413-34-5 | |
| C20H20N8Na2O5 | |
| 250mg | |
| Hygroscopic | |
| Soluble in water | |
| CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].[Na+].[Na+] | |
| 498.411 | |
| CHEBI:50679 | |
| 98.5% |
| 823°C | |
| MFCD00274560 | |
| UN2811 | |
| methotrexate disodium salt, sodium methotrexate, ledertrexate, methotrexate sodium, mtx disodium, methotrexate disodium, unii-3ig1e710zn, trexall, mexate, methotrexate lpf | |
| DASQOOZCTWOQPA-GXKRWWSZSA-L | |
| disodium;(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioate | |
| 11329481 | |
| 498.4 | |
| Methotrexate disodium salt |
Safety and Handling
Product Identifier
Signal Word
Hazard Category
Hazard Statement
Precautionary Statement
Supplemental information
- Methotrexate disodium salt
Signal Word
- Danger
Hazard Category
- Acute toxicity Category 3
- Serious eye damage/eye irritation Category 2
- Germ cell mutagenicity Category 1B
- Skin corrosion/irritation Category 2
- Specific target organ toxicity Category 3
Hazard Statement
- H301-Toxic if swallowed.
- H315-Causes skin irritation.
- H319-Causes serious eye irritation.
- H335-May cause respiratory irritation.
- H340-May cause genetic defects.
- H360FD-May damage fertility. May damage the unborn child.
Precautionary Statement
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
- P302+P352-IF ON SKIN: Wash with plenty of water/soap.
- P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
- P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P312-Call a POISON CENTER/doctor/if you feel unwell.
Supplemental information
- MIXTURE LIST-Contains : Disodium N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate
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