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Tocris Bioscience™ Me VH 032, amine

Product Code. 18707376
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Quantity:
100 mg
Unit Size:
100mg
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Product Code. 18707376 Supplier Tocris Bioscience™ Supplier No. FAB9610U100UG

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Amine functionalized VHL ligand for PROTAC™ research

Me VH 032, amine is a derivative of the von Hippel-Lindau (VHL) ligand, VH 032 for use as a precursor to a PROTAC® that hijacks VHL as the E3 ubiquitin ligase component. Me VH 032, amine is supplied with a primary amine functional handle, for ready conjugation to a linker/target protein ligand. Introduction of the methyl group at the benzylic position of VH 032 is associated with improved binding affinity.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

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TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material (4R)-3-Methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-L-prolinamide dihydrochloride
CAS 2504950-56-3
Quantity 100 mg
Target Degrader Building Blocks
Molecular Formula C23H32N4O3S.2HCl
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