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Invitrogen™ MARK1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA532915
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Description
Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Horse, Rabbit (100%); Dog, Bovine, Panda (95%); Rat, Hamster, Elephant, Platypus (89%); Mouse, Opossum, Turkey, Chicken, Lizard (84%). For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
MARK1 (MARK) is a serine/threonine kinase which is involved in cytoskeletal organization and biogenesis. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. MARK1 is involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
Specifications
| MARK1 | |
| Polyclonal | |
| Unconjugated | |
| MARK1 | |
| AW491150; B930025N23Rik; ELKL motif serine/threonine-protein kinase 3; ELKL motif serine-threonine protein kinase 3; Emk3; KIAA1477; MAP/microtubule affinity regulating kinase 1; MAP/microtubule affinity-regulating kinase 1; MARK; MARK1; mark1 {ECO:0000312; microtubule affinity regulating kinase 1; mKIAA1477; mPar-1c; PAR1 homolog c; Par1c; Par-1c; RGD:619882}; serine/threonine-protein kinase MARK1 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 100054005, 100339168, 4139 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin) | |
| 1 mg/mL | |
| PBS with 0.1% sodium azide | |
| Q9P0L2 | |
| MARK1 | |
| Synthetic 19 amino acid peptide from N-terminus of human MARK1. | |
| 50 μg | |
| Primary | |
| Human, Rabbit, Monkey, Horse | |
| Antibody | |
| IgG |
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