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Invitrogen™ LRAT Polyclonal Antibody
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Product Code. 16633495
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Quantity:
100 μL
Unit Size:
100µL
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16633495 100 μL 100µL
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Product Code. 16633495 Supplier Invitrogen™ Supplier No. PA599243

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total LRAT.

Lecithin retinol acyltransferase (LRAT) is a membrane bound enzyme that catalyzes the transfer of an acyl group from the sn-1 position of lecithin to vitamin A which generates all-trans-retinyl esters (tREs) in the liver, some extrahepatic tissues, such as the lung, and retinal pigmented epithelium. LRAT can also exchange palmitoyl groups between RPE65, a tRE binding protein essential for vision, and tREs, which is important for the operation of the visual pathway. LRAT is essential for the dietary mobilization, transport, and storage of vitamin A as well as the synthesis of the visual pigment chromophore. LRAT monomers interact in membranes to form homodimers through disulfide bond formation. A loss of LRAT correlates with an early onset severe retinal dystrophy and severe retinyl ester deprivation, while a reduction in LRAT expression may be associated with invasive bladder cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LRAT
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene LRAT
Gene Accession No. O95237, Q9JI60, Q9JI61
Gene Alias 1300010A18Rik; AI449251; LCA14; Lecithin retinol acyltransferase; lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase); lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase); Lrat; Phosphatidylcholine--retinol O-acyltransferase; phosphatidylcholine-retinol-O-acyltransferase
Gene Symbols LRAT
Host Species Rabbit
Immunogen A synthesized peptide derived from human LRAT(Accession O95237), corresponding to amino acid residues Y118-C168.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 64047, 79235, 9227
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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