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Linifanib, MedChemExpress

Product Code. 16481316
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Product Code. 16481316 Supplier Medchem Express Supplier No. HY50751

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Description

MedChemExpress Linifanib (ABT-869) is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family with IC50s of 4, 3, 66, and 4 nM for KDR, FLT1, PDGFRβ, and FLT3, respectively. Linifanib shows prominent antitumor activity. Linifanib has much less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. Linifanib is a specific miR-10b inhibitor that blocks miR-10b biogenesis.

Linifanib (ABT-869) is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family with IC50s of 4, 3, 66, and 4 nM for KDR, FLT1, PDGFRβ, and FLT3, respectively. Linifanib shows prominent antitumor activity. Linifanib has much less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. Linifanib is a specific miR-10b inhibitor that blocks miR-10b biogenesis.

Specifications

Chemical Name or Material Linifanib
CAS 796967-16-3
Color Off-White
Purity Grade Notes Research
Molecular Formula C21H18FN5O
Quantity 200 mg
Synonym ABT-869 AL-39324
Solubility Information DMSO : 13.16 mg/mL (35.06 mM; Need ultrasonic)
SMILES O=C(NC1=CC=C(C2=C3C(N)=NNC3=CC=C2)C=C1)NC4=C(C=CC(C)=C4)F
Molecular Weight (g/mol) 375.4
Formula Weight 375.4
Percent Purity 98.3%
Grade Research
Physical Form Powder
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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