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Lifitegrast, MedChemExpress

Product Code. 16497738
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Product Code. 16497738

Brand: Medchem Express HY19344

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Description

MedChemExpress Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast can be used for researching dry eye disease.

Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast can be used for researching dry eye disease.

Specifications

Chemical Name or Material Lifitegrast
CAS 1025967-78-5
Color Off-White
Purity Grade Notes Research
Molecular Formula C29H24Cl2N2O7S
Quantity 10 mg
Synonym SAR 1118 SHP-606
Solubility Information DMSO : ≥ 29 mg/mL (47.12 mM)
SMILES O=C(O)[C@H](CC1=CC=CC(S(=O)(C)=O)=C1)NC(C2=C(Cl)C3=C(CN(C(C4=CC=C5C=COC5=C4)=O)CC3)C=C2Cl)=O
Molecular Weight (g/mol) 615.48
Formula Weight 615.48
Percent Purity 99.09%
Grade Research
Physical Form Solid
For Use With (Application) COVID-19-immunoregulation
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Research purposes only

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