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  5. STEMCELL Technologies LDN193189 (Dihydrochloride)

STEMCELL Technologies LDN193189 (Dihydrochloride)

Product Code. 17120032
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Product Code. 17120032 Supplier STEMCELL Technologies Supplier No. 72147

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Description

BMP pathway inhibitor; Inhibits ALK1, ALK2, ALK3, and ALK6

  • LDN193189 is a potent inhibitor of the bone morphogenetic (BMP) pathway, inhibiting ALK1, ALK2, ALK3, and ALK6 (IC50 = 0.8, 0.8, 5.3, and 16.7 nM respectively; Sanvitale et al.) It is a derivative of Dorsomorphin (Catalog #72102) that is typically used at approximately 100-fold lower concentrations (Sanvitale et al.; Vogt et al.) This product is supplied as the dihydrochloride salt of the molecule and it is the most soluble version of LDN193189
  • Promotes differentiation of neural progenitor cells from human pluripotent stem cells (Chambers et al.; Kriks et al.)
  • Promotes differentiation of neural crest cells from human pluripotent stem cells (Kreitzer et al.)
  • Promotes differentiation of anterior foregut endoderm from human and mouse pluripotent stem cell-derived definitive endoderm (Kearns et al.)
  • Promotes differentiation of sensory epithelial cells of the inner ear from mouse embryonic stem cells (Koehler et al.)
  • Inhibits prostate and breast cancer tumor growth (Balboni et al.; Lee et al.)
  • Prevents ovarian cancer cell proliferation (Tsai et al.)

Specifications

CAS 1435934-00-1
Synonym DM-3189
Quantity 10 mg
Molecular Formula C25H22N6 · 2HCl
Purity >98%
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