Invitrogen™ Lamin B1 Monoclonal Antibody (119D5-F1)

Description

MA1-06103 detects lamin B in human, mouse, rat, bovine, ovine, rabbit, zebrafish, and canine samples. MA1-06103 has sucessfully been used in immunocytochemistry, immunohistochemistry, ELISA, and flow cytometry procedures. The MA1-06103 immunogen is purified rat liver lamins.

Lamin B1 is a key member of the nuclear lamina structure, encoded by the LMNB1 gene. It is part of the B-type lamins, ubiquitously expressed across all mammalian cells, providing structural integrity and mechanical support by forming a meshwork along the inner nuclear membrane. Lamin B1 is involved in maintaining the shape and stability of the nucleus, playing a critical role in cellular processes such as genome organization, DNA replication, and transcription regulation. The lamin filaments are type V intermediate filament proteins, enabling the nucleus to withstand mechanical stress and preserve its functionality. Lamin B1's expression and dynamics vary during cell differentiation, influencing gene regulation. Its location within the euchromatin-enriched section of the genome suggests potential roles in chromatin organization and the epithelial-to-mesenchymal transition. Governed by complex interactions with other proteins, lamin B1 is integral to cellular architecture and health, with variations in its levels linked to developmental and disease processes. Recent studies have highlighted the importance of understanding the role and dynamics of lamin B1 in human-induced pluripotent stem cells and germ layer cells, offering insights into differentiation-dependent changes and their implications for nuclear structure.