Epredia™ Lab Vision™ Factor XIII A Ab-1 Mouse Monoclonal Antibody, 200μg/mL, BSA and azide

Description

Detect factor XIII in both reduced and non-reduced forms. This abtibody does not react with human Factor XIII B-chain or human Factor XII. Factor XIII is a Β-globulin found in plasma and is composed of two subunits. Factor XIII-A is the catalytic subunit and is a dimer of M.W. 160 kDa. Factor XIII is present in plasma as an alpha2Β2 heterodimer (M.W. 320 kDa); whereas in platelets, only the α2 unit exists. Factor XIIIa is a dermal dendrocyte marker and shows variable reaction with these types of tumors. It can be used for histiocytic phenotyping and has been reported to mark capillary hemangiomas and tumors of the central nervous system. Factor XIII has also been used with CD34 to differentiate between dermatofibroma and dermatofibrosarcoma protuberans.

Host Species: Mouse

Clone: AC-1A1

Isotype: IgG1/κ

Species Reactivity: Human. Others not known.

Epitope: Not determined

Immunogen: Recombinant protein corresponding to A-subunit of coagulation Factor XIII

Molecular Weight: 160 kDa (unreduced dimmer); 80 kDa (reduced monomer)

Positive Control: Recombinant human Factor XIII A-subunit; Capillary hemangioma, dermatofibroma and placenta

Cellular Localization: Cytoplasmic and nuclear

Recommended for:

• Immunohistochemistry (Formalin/paraffin)
• Western Blotting