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L-685458, MedChemExpress

Product Code. p-200101426
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Quantity:
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5 mg
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Product Code. 16450218

Brand: Medchem Express HY19369

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Description

MedChemExpress L-685458 is a potent transition state analog (TSA) γ-secretase inhibitor (GSI).

L-685458 inhibits amyloid β-protein precursor γ-secretase activity with IC50 of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested. L685458 inhibits γ-secretase-mediated cleavage of APP-C99 and Notch-100 with IC50s of 301.3 nM and 351.3 nM, respectively. L-685458 can be used for the research of alzheimer’s disease (AD) and cancers.

Specifications

Chemical Name or Material L-685458
Physical Form Solid
CAS 292632-98-5
Color White
Quantity 5 mg
Purity Grade Notes Research
Molecular Formula C39H52N4O6
For Use With (Application) Cancer-programmed cell death
Synonym L-685,458
Solubility Information DMSO : 83.3 mg/mL (123.80 mM; Need ultrasonic and warming)
SMILES O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CC(C)C)NC([C@H](CC2=CC=CC=C2)C[C@@H](O)[C@@H](NC(OC(C)(C)C)=O)CC3=CC=CC=C3)=O)=O
Molecular Weight (g/mol) 672.85
Formula Weight 672.85
Percent Purity 99.09%
Grade Research
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Research purposes only

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