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Tocris Bioscience™ KH-4-43

Product Code. 30306125
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30306125 5 mg
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Product Code. 30306125 Supplier Tocris Bioscience™ Supplier No. 8091/5

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Description

Selective CUL4 inhibitor

KH-4-43 is a selective CUL4 inhibitor (Kd = 83 nM). KH-4-43 inhibits the ubiquitination of CK1α by CRL4CRBN in vitro. Treatment of cells with KH-4-43 causes accumulation of the E3 CRL4 substrate CDT1. KH-4-43 suppresses the growth of human tumor xenografts in mice.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 3-[1-(4-Chlorophenyl)-1H-pyrazol-4-yl]-7,8-dihydroxy-2-(trifluoromethyl)-4H-1-benzopyran-4-one
CAS 2813310-07-3
Quantity 5 mg
Target Ubiquitin Ligase (E3) Inhibitors
Molecular Formula C19H10ClF3N2O4
Purity 0.98
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