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  5. Tocris Bioscience™ Kainic acid (synthetic)

Tocris Bioscience™ Kainic acid (synthetic)

Product Code. 18034912
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Quantity:
1 mg
10 mg
50 mg
Unit Size:
10mg
1mg
50mg
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Product Code. 18034912

Brand: Tocris Bioscience™ 7065/1

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This item is not returnable. View return policy

Description

Kainate agonist; excitant and neurotoxin

Kainic acid, also known as kainate, is a selective agonist of kainate ionotropic glutamate receptors (EC50 = 0.6 μM to 7.4 μM) and a partial agonist at AMPA receptors (EC50 = 31 μM to 170 μM). Kainic acid is used to model epilepsy in vivo and to study the mechanisms of neurodegeneration and neurocytosis induced by excess stimulation by kainic acid. Kainate is shown to be involved in amyloidogenic processing of amyloid precursor protein and Aβ peptides in Alzheimers. Synthetic version of Kainic acid (Cat. No. 0222) Related compounds include the kainate receptor agonist Domoic acid (Cat. No. 0269) and the antagonist NBQX (Cat. No. 0373).
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Specifications

Chemical Name or Material (2 S,3 S,4 S)-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid
CAS 487-79-6
Quantity 1 mg
Molecular Formula C10H15NO4
Purity 98%
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