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STEMCELL Technologies IWP-4

Product Code. 17190082
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Product Code. 17190082 Supplier STEMCELL Technologies Supplier No. 72554

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Description

WNT pathway inhibitor; Inhibits Porcupine

  • Inhibitor of WNT Production-4 (IWP-4) inhibits WNT signaling by inactivating Porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating WNT proteins, which is essential for WNT signaling ability and secretion (Chen et al.) IWP-4 impairs WNT pathway activity in vitro with an IC50 value of 25 nM (Chen et al.)
  • Promotes cardiomyocyte differentiation in human pluripotent stem cells after treatment with CHIR99021 (Lian et al.), 2012, 2013; Sequiera et al.)
  • Promotes cardiomyocyte differentiation in human embryonic stem cells following primitive streak induction with BMP4 and Activin A (Hudson et al.)

Specifications

CAS 686772-17-8
Synonym Inhibitor of Wnt Production-4
Quantity 10 mg
Molecular Formula C23H20N4O3S3
Purity ≥95%
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