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Invitrogen™ IL-1 beta Human ProQuantum Immunoassay Kit

Measure cytokine proteins with small sample consumption and high sensitvity on a qPCR instrument

Brand:  Invitrogen™ A35574

678.30 EUR valid until 2024-12-31
Use promo code "21989" to get your promotional price.



Additional Details : Weight : 0.22720kg

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Product Code. 15950463

  • 748.00 € / 96 reactions
Estimated Shipment: 20-03-2024
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For Research Use Only. All usage must comply with product instructions.


Description

Description

Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes,macrophages,and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes,which are multi-protein complexes that respond to pathogens,stress conditions,and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form,which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form,secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors,IL-1RI and IL-1RII,both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA),a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.
Specifications

Specifications

P01584
<0.05pg/mL
ProQuantum
Human
qPCR Instruments
IL-1; IL1-BETA; IL1F2
FAM™
RUO
-20°C
30 min.
0.064 – 10000pg/mL
Taqman™ Real-time PCR
Plasma, Serum, Supernatant
Cytokine protein quantitation
3553
Assay Dilution Buffer<Br>Antibody-Conjugate A<Br>Antibody-Conjugate B<Br>Antibody-Conjugate Dilution Buffer<Br>Standard<Br>Master Mix<Br>Ligase
96 Tests
Serum, 2-5 μL; Plasma, 2-5 μL; Supernatant, 2-5 μL
Human
2 hr.
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