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  5. Tocris Bioscience™ Indibulin

Tocris Bioscience™ Indibulin
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Product Code. 18015502
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18015502

Brand: Tocris Bioscience™ 3728/10

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Description

Microtubule destabilizer

Indibulin is a microtubule destabilizer that blocks tubulin polymerization (IC50 = 0.3 μM). Blocks cell cycle progression at metaphase and displays antitumor activity against a variety of malignancies in vitro (IC50 values ranging from 0.036 - 0.285 μM). Induces complete tumor remission in the Yoshida AH13 rat sarcoma model in vivo. Lacks neurotoxicity due to an ability to discriminate between posttranslationally modified tubulin in mature neuronal microtubules and less-modified tubulin present in immature neuronal or nonneuronal microtubules. Displays oral availability and efficacy towards MDR tumor cells.
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Specifications

Purity >98%
Quantity 10 mg
Product Type Indibulin
Molecular Weight (g/mol) 389.83
Inhibitors Indibulin

For Research Use Only

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