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Invitrogen™ IL23R Monoclonal Antibody (218213)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA523935
This item is not returnable.
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Description
This antibody does not cross-react with recombinant mouse (rm) IL-23 R. Reconstitute at 0.5 mg/mL in sterile PBS.
IL-23R is a 629 aa, novel subunit of the receptor for cytokine IL23A/IL23 which pairs with the receptor molecule IL12RB1/IL12R beta 1and thus take part in IL23A signaling. Signal transduction analysis confirms that this protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. Alternative splicing results in six spliced isoforms of IL-23R. Reports suggest that IL-23R plays an important role in psoriasis pathogenesis and is also a potential therapeutic target in inflammatory bowel disease.
Specifications
| IL23R | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with 5% trehalose and No Preservative | |
| Q5VWK5 | |
| Il23r | |
| Mouse myeloma cell line NS0-derived recombinant human IL-23 R Gly24-Ile354. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG2b |
| Western Blot | |
| 218213 | |
| Unconjugated | |
| Il23r | |
| IBD17; IL 23R; IL-23 receptor; IL23R; IL-23R; interleukin 23 receptor; interleukin 23 receptor-like; interleukin-23 receptor | |
| Mouse | |
| Protein A/G | |
| RUO | |
| 149233 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Lyophilized |
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