IL17RC Polyclonal Antibody, Invitrogen™

Description

Immunogen sequence: WDSDILCLPG DIVPAPGPVL APTHLQTELV LRCQKETDCD LCLRVAVHLA VHGHWEEPED EEKFGGAADS GVEEPRNASL QAQVVLSFQA YPTARCVLLE VQVPAALVQF GQSVGSVVYD CFEAALGSEV RIWSYTQPRY EKELNH Highest antigen sequence identity to the following orthologs: Mouse - 73%, Rat - 76%.

This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling.