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Invitrogen™ IFN alpha Polyclonal Antibody

Product Code. 10493225
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Quantity:
2x10^4 units
Unit Size:
208 units
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10493225 2x10^4 units 208 units
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Product Code. 10493225 Supplier Invitrogen™ Supplier No. 321001

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Description

Rabbit Polyclonal Antibody

Specificity: Neutralizes mouse interferon alpha. Activity: Interferon was titrated with the use of the cytopathic effect inhibition assay using L929 cells, where 5 unit/mL of interferon was necessary to produce an endpoint of 50%. One neutralization unit is defined as the amount of serum required to neutralize one unit of mouse IFN alpha to an endpoint of 50%. Store at -20°C for short-term use (less than 6 months). For long-term storage, aliquot and store at -70°C or below for retention of full activity. Refreezing should be done on dry ice or in a dry ice/alcohol bath. Further dilution of the product should be in buffers containing protein such as 0.1% BSA. Packaged by and distributed for PBL Assay Science.

IFN alpha (Interferon alpha) is a Type I interferon belonging to a family of structurally related, species-specific proteins exclusive to vertebrates. The interaction of IFN-alpha with its receptor component result in the activation of a number of signaling pathways which are mainly involved in innate immune response against viral infection. In humans, the gene for IFN alpha is located on on chromosome 9. The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. IFN alpha is produced primarily by plasmacytoid dendritic cells, is a potent component of the anti-viral innate immune response and modulates adaptive immunity. Diseases associated with the dysfunction of IFN alpha include Hepatitis C and Hepatitis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IFN alpha
Applications Neutralization
Classification Polyclonal
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Whole serum, PBS with no preservative
Gene IFNA1
Gene Accession No. P01572, P01573
Gene Alias alpha-2a interferon; Gm12597; ifa; Ifa1; Ifa2; IFL; IFN; IFN alpha; IFN alpha 1/13; IFN alpha 1b; IFN α; IFN1@; IFNA; IFNA@; IFNA1; IFNA13; Ifna15; Ifna2; IFNA2A; IFNA2B; IFNA2C; IFNA3; IFNA6; Ifnaa; IFNAalphaIFN-alpha-1/13; IFNalpha; IFN-alpha; IFN-alpha 1b; IFN-alpha1; IFN-alpha-1; IFN-alpha-1/13; IFN-alpha-2; IFN-alpha-6; IFN-alphaA; IFN-alphaD; IFN-gamma; IFNα; INFA2; interferon; interferon alpha; interferon alpha 1; Interferon alpha 13 (IFNA13); interferon alpha 15; interferon alpha 1b; interferon alpha 2; interferon alpha 2a; interferon alpha 2b; interferon alpha A; interferon alpha family gene 1; interferon alpha family, gene 2; Interferon alpha leukocyte (IFL); interferon alpha protein; interferon alpha-1; Interferon alpha1 (IFNA1); interferon alpha-1 precursor; interferon alpha-1/13; Interferon alpha-1/13 (IFN-alpha-1/13); Interferon alpha-2; Interferon alpha-A; Interferon alpha-D; Interferon alpha-D (IFN alphaD); interferon type A1/A2; interferon type A3; interferon, alpha 1; interferon, alpha 2; interferon-alpha; interferon-alpha 1; interferon-alpha1; interferon-alpha-6; leIF A; LeIF D; MGC138207; MGC138505; MGC138507; MuIFN-alpha-A; novel interferon alpha (Ifna) family member; OTTMUSG00000007655
Gene Symbols IFNA, IFNA1, Ifna15, IFNA2
Host Species Rabbit
Immunogen Recombinant mouse interferon alpha.
Quantity 2x10^4 units
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 111654, 15962, 15965, 242517
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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