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Hygromycin B

Product Code. 15413419
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Quantity:
100 mg
250 mg
1 g
Unit Size:
100mg
1g
250mg
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Product Code. 15413419

Brand: Thermo Scientific Alfa Aesar J60681.MD

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Descrizione

Hygromycin B, CAS # 31282-04-9, is an aminoglycoside compound showing antibiotic activity that kills bacteria through the inhibition of protein synthesis. It also presents anthelmintic activity. | CAS: 31282-04-9 | C20H37N3O13 | 527.524 g/mol

An aminoglycoside antibiotic that kills bacteria by inhibiting protein synthesisHygromycin B is used for the selection and maintenance of prokaryotic and eukaryotic cells that contains the hygromycin resistance gene. This gene is frequently used as a selectable marker in research on plants. It stabilizes the transfer ribonucleic acid (tRNA)-ribosomal acceptor site, thereby inhibiting translocation. In addition to this, it serves as an aminoglycosidic antibiotic which inhibits protein synthesis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Hygromycin is an aminoglycosidic compound that shows antibiotic activity. It is produced by Streptomyces hygroscopicus
  • Hygromycin acts against both prokaryotic and eukaryotic cells, having the ability to inhibit protein synthesis. It also stabilizes the transfer ribonucleic acid (tRNA)-ribosomal acceptor site, thereby inhibiting translocation. This compound prevents ribosome translocation during translation elongation by binding the 30S rRNA proximal to the ribosomal E, P, and A sites

Application

  • In clinical and plant research, this compound can be used as a marker to select and maintain prokaryotic and eukaryotic cells containing the hygromycin resistance gene
  • Hygromycin also presents an anthelmintic activity against nematode parasites of chickens
TRUSTED_SUSTAINABILITY

Identificatori chimici

CAS 31282-04-9
Molecular Formula C20H37N3O13
Molecular Weight (g/mol) 527.524
MDL Number MFCD06795479
InChI Key GRRNUXAQVGOGFE-BBMONYMYSA-N
PubChem CID 134129613
IUPAC Name (3'S,3aS,4S,4'S,5'R,6R,6'R,7R,7aS)-4-[(1R,2S,3R,5S,6S)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy-6'-[(1S)-1-amino-2-hydroxyethyl]-6-(hydroxymethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,2'-oxane]-3',4',5',7-tetrol
SMILES CNC1CC(C(C(C1O)OC2C3C(C(C(O2)CO)O)OC4(O3)C(C(C(C(O4)C(CO)N)O)O)O)O)N

Specifica

Type Hygromycin B
Physical Form Lyophilized Powder
Color Brown
Quantity 250 mg
UN Number UN3462
Merck Index 14,4852
Solubility Information Miscible with water,methanol,buffer solution and ethanol; Immiscible with less polar solvents.
Formula Weight 527.53
Chemical Name or Material Hygromycin B

Sicurezza e movimentazione

compliance-icons compliance-icons compliance-icons
Identificativo prodotto
  • Hygromycin B
 Avvertenza
  • Danger
 Categoria di pericolo
  • Acute toxicity Category 1
  • Acute toxicity Category 4
  • Serious eye damage/eye irritation Category 1
  • Respiratory sensitiser Category 1
  • Skin sensitiser Category 1
 Indicazioni di pericolo
  • H300-Fatal if swallowed.
  • H310-Fatal in contact with skin.
  • H317-May cause an allergic skin reaction.
  • H318-Causes serious eye damage.
  • H330-Fatal if inhaled.
  • H334-May cause allergy or asthma symptoms or breathing difficulties if inhaled.
 Consigli di prudenza
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P302+P352-IF ON SKIN: Wash with plenty of water/soap.
  • P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
  • P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P310-Immediately call a POISON CENTER/doctor/.
  • P330-Rinse mouth.
 Informazioni supplementari
  • MIXTURE LIST-Contains : Hygromycin B
SDS

RUO – Research Use Only

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